I have a hard time with this question.. I too have big/small dogs that live in harmony, but I know that isn't always the case.I have two yorkies, a bichon, and an english mastiff.I think if I were to place one of my puppies in a home with a large dog..I would definitely want to know it's temperment, age, inside/outside, if it is crated when left at home/unsupervised (if inside), and things along those lines.At the shelter I worked for we would have them bring other dogs in for a visitation to see how they would react to each other.It would also depend on how much the person knows about their dog(s) .. I'm not going to lie, ours don't get along 100% of the time.. our mastiff has "food agression" so we have to feed her either on our front porch or in her crate and we can't leave food laying around.. anyways.. don't know if this is much help, but I guess it depends on the individual dog/situation. You could always try "safer" testing the dog/dogs involved to find any problems (food agression/ dog-to-dog agression/ rawhide agression/ possession agression) before they occur
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