Do not give combo shots, that way if there is a reaction you can see what did it. And don't give lepto. My husband is a vet and wouldn't vaccinate Ranger for Lepto. Also, after the puppies have had all their shots, we only do rabies. We may do another set of booster shots after three or so years, but we never do yearly boosters, it is very hard on their systems. Good luck, Amanda |