Our first yorkie, Bandit, was about 3.5-4 pounds. He had liver shunt and died when he was about 4 months old. Now, he came from a puppymill, and I'm sure that had something to do with it, but I think he could've fought it if he was bigger.
Knowing what I know now, I would not get a dog expected to stay that small - unless I was getting Bandit again.