Regular Heartgard is Ivermectin. Heartgard Plus adds Pyrantel (a dewormer) for all the other worms. So when you give Heartgard Plus, you are giving an unnecesary ingredient. Dogs don't need to be dewormed once a month.
Interceptor is milbemycin. This kills heartworm larvae and controls or kills other worms.
I use Interceptor but see no problem with regular Heartgard. I like the fact that Interceptor deals with worms without extra ingredients but this is just a bonus and isn't necessary. I would not use Heartgard Plus if I didn't have to.
It is very important for your vet to do a fecal atleast once a year.
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