Well, I know the one I just got from Michigan, flew out of Lansing, then went to Detroit, and then to Greenville/spartanburg SC...she did fine on that trip, but, it wasn't that long, and I only had an hour drive home..But the one from Germany, he had a long flight to PA, then from PA to Atlanta, then a 2 hour drive home, he was okay, but, I think they must have given him something to knock him out...I think it's way too much on them when they're in those crates for the whole day..