 Atopica
I did a bit of research on Atopica, and it has an effect on the T cells.
The most frequently observed undesirable effects include gastrointestinal disturbances such as vomiting, mucoid or soft stool and diarrhea. They are mild and transient and generally do not require the cessation of the treatment. Very rarely (muscle cramps, muscle weakness) anorexia, gingival hypertrophy, veruciform lesions or change of hair coat have been reported.The efficacy and safety of cyclosporine has neither been assessed in dogs aged less than 6 months weighing less than 2 kg nor in breeding dogs or pregnant or lactating bitches. It is recommended to clear bacterial and fungal infections before treatment with ATOPICA. But infections are not necessarily a reason for drug withdrawal if they occur during treatment. As cyclosporine inhibits T-lymphocytes, it may decrease the immune response in case of malignancy. A complete clinical examination should be performed before treatment. Lymphadenopathy observed on treatment with cyclosporine should be regularly monitored.
In contrast to humans, there is no evidence of cyclosporine kidney toxicity and increased blood pressure in dogs.
Various drugs are known to competitively inhibit or induce the enzymes involved in the metabolism of cyclosporin, in particular cytochrome P450 (CyP 3A 4). In clinically relevant cytochrome P450-mediated interactions an appropriate adjustment of ATOPICA dosage might be required. Ketoconazole is the only drug known to lead to a clinically relevant increase of the blood concentration of cyclosporin in dogs. |