We have two large cats that reside with my Daisy. She is only about 4 lbs, one of our cats in near 20 lbs. Both are cats are not declawed. We considered it, but after reading up on declawing we felt we it wasn't the right thing to do.
That said, Daisy does chase them from time to time, but that is usually when one cat is getting into a spat with the other cat (Daisy breaks it up) or if the cat knocks something over and makes loud noises. The cats will run and just jump up onto something that they know Daisy cannot reach.
Otherwise, they do get along well. They respect Daisy's space - her food, her bed, her treats - and she is nice to them in return.
It does take time for the cats to adjust. Just make sure to give attention to all of them to avoid jealousy issues.