Yes, but it depends on what you consider a reasonable amount of time
Loki asks to go out and when he is active he asks every hour. When he naps (half the day) it could be like 3 hours. When I have to crate him he can hold it at least 5. He is 3, and has been trained since he was about 10 months.
We didn't get Sammy until she was almost a year old. 6 months later she is *almost* trained but not quite there yet. She knows what to do and she will ask but if we don't get it she will just go in a corner somewhere rather than continue to try to get our attention. We are working on it.
Loki rings a bell to go out and if I don't respond he will come find me. Sam barks, spins in a circle, looks at the door, paces, or about 15 other things she randomly chooses to let us know. She occasionally rings the bell.
Also - mine sleep through the night, but Loki didn't until he was almost a year old. We always had to take him out an extra time at night.