Yes I was on Prozac years ago and I hated it, I did not care about anyone or anything...It was horrible...I have since been on and off of all different kinds for about 15 yrs now....I just got off of the cymbalta and the withdrawals from it was nothing nice...oh my gosh I dont even want to think about that right now it was such a nightmare...I am back on wellbutrin xl for the second time now for my depression...I really feel that each one of these medicines react different on different people you will just have the find that one that is right for YOU...Good Luck and I hope you find the one that helps you the most....