Good luck with your travel. I would not medicate with over the counter meds. 
If your dogs tend to get stressed talk to your vet about meds for them. 
You don't need your vacation to be stressful because of a sick pup. 
When I flew home with my puppy, I let all my seatmates know I had a puppy in the carrier. They were all very nice and asked if I needed help with anything. I also purposely booked my seat last row in the back by the window. Nobody had any problems with her, I even took her out and had her on my lap wrapped in a blanket. She did get airsick so be prepared just in case. I had brought her a couple of tshirts, the plane tends to be a bit drafty, especially on the floor.        |