Hi 3puppies4m3...congratulations on your new girl! I wouldn't use the Advantix again if it were me and I think I would even check with another vet. I've never used that brand. I saved this link a while back, it has the information you're looking for regarding anesthesia:
http://www.shooterdog.com/alexfaq3.htm As for the grooming, just take it slow. Jo didn't like it at first but now he sits pretty still, he's only 7 months though. I find it easier to do his nails if someone holds him while I clip and we're still working on learning to brush...he's a tad bit touchy about his mouth since he started teething.