thanks for fast response and trying to help Patti, I dont get it I have used it before once and he didnt react.....He had rabies shot friday and was due for revolution that day but i wanted for this reason...if he reacts I would know which it is....Revolution or rabies...He odes not act to be in pain just a bit itchy. Now he is sleeping very sound and not itching. I absolutely hate this...i seriously freak myself right out!!!!