we;ve done it.. its stressful i find... but it's do-able
if your pup is a barker. i'd said it might be harder than it's worth but Layla doesn't bark so she was fine. my parents check in and ask for a room on the ground floor close to the back door (if they ask we just say we have stuff in our car we want to be able to check on regularly) then they pull the car around the back and i put Layla in her purse carrier and sneak her in... we do not bring toys that squeek and always have the tv on just in case she makes a noise
we take her out to potty the same way we brought her in, through the back door in her carrier... i'm always SO happy when it is morning and we can leave.. lol... it definitly is stressful but good luck