I don't want to scare anybody but this is something that happened to my baby 2 years ago.
Baby is 3 lbs, she had always been current on all shots and we had never had any problems in the past. Took her in for her yearly shots and exam. Everything was fine. Got the combo shots and she always is very timid and a big mommy's baby. I had been standing in line for 20 minutes to pay and get my tag, I was getting very agitated. (It was a blessing) I finally paid and walked outside and put her down to go potty. I will never forget how she just fell over and her tounge was haning out of her mouth. I went tearing back inside and they took her to the back. I was just in tears she looked like she was dead. My vet wanted me to come to the back and talk to her because she was not reacting and they thought my voice and touch might help. She was hooked up to 2 different IV's (her legs are like small sticks) she heard my voice as I rounded the corner she had raised her head. I talked to her and loved on her and she was responding. They kept her the rest of the day.
That 20 minutes of standing in line was the difference between Baby living or dying.
Baby no longer gets the combo. She gets Benydryl before each shot and spends the day at the vet. It may never happen again but I'm not taking the chance.
I sit with my other 2 girls at the vet after shots just to be sure!