My Pointer has gotten car sick from the day we brought him home when he was 8 weeks old. He gets very nervous and drools and throws up whenever he travels. Before we take him to the vet or in the car we give him Benadryl to help with this. However he is 97 pounds. SO I do not know about Benadryl on a little Yorkie baby. The benadryl does not help him 100%...it justs relaxes him so he does not drool as much and get as nervous as his panic attacks are our main concern with that