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07-14-2013, 04:46 AM | #1 |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
| Rabies Vax Study Summary Rabies Challenge Fund Summary of The Rabies Challenge Fund Duration of Immunity Study A study conducted according to the USDA Title 9 canine vaccine licensing standard, was begun more than five years ago. The purpose was to determine if the duration of immunity from commercially available rabies vaccines was longer than 3 years, with the goal of extending state-mandated rabies boosters for dogs to 5, and then 7 years. The first rabies vaccine studied was selected based on the superior response it provided in the USDA challenge trials for licensing. Another licensed rabies vaccine was administered to a second, separate group of dogs 2 years after the first study began so that a minimum of two commercially available rabies vaccines would be tested. The second vaccine selected is the one currently administered to a very high percentage of dogs. Both vaccines demonstrated excellent protection based on antibody testing for each of the first three study years. However, fewer than 30% of dogs in the first vaccine group, now five years since vaccination, had serum rabies antibody titer levels considered positive on the Rapid Fluorescent Focus Inhibition Test (RFFIT). (Note: RFFIT is the rabies titer standard established by the Centers for Disease Control within the USA [0.1 IU/mL] and the World Health Organization [0.5 IU/mL] for export to other rabies-free locations to be adequate to protect humans, not dogs, against rabies. There is no established standard for dogs, which means that the human standards must be extrapolated when assessing protection for other species.) Some of the dogs with low or no detected RFFIT antibody were further tested to determine if they had “immunologic memory”. This in vitro test shows whether memory is present or not, even in cases when serum antibody cannot be detected at a level considered to be protective. The results of this further testing indicated that most of the dogs vaccinated five years ago, even without a positive RFFIT, do have “immunologic memory”. As soon as a USDA licensed facility can be reserved, we plan to challenge some of those dogs with rabies virus to determine if the memory response demonstrated actually correlates with protection. Our conclusion from studies with the initial rabies vaccine is that the immunity conferred by that product, and assessed by the in vitro RFFIT, was excellent for the first three years, but declined during the fourth year, and continued to drop during the fifth year. The second vaccine group, which is now three years from vaccination, will remain on study for at least two more years. Principal Investigator, Dr. Ronald Schultz of the University of Wisconsin School of Veterinary Medicine, is preparing results of the study and details described above for scientific peer review and publication. That data will be made available to the public as soon as our paper has been accepted for publication. After completion of the peer-review process, it is our hope that this data will establish the world’s first canine rabies titer standard. If this data is further verified by challenge, it will provide a solid scientific base enabling states to incorporate titer clauses into their laws. PERMISSION GRANTED TO CROSS-POST
__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND |
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07-14-2013, 09:06 AM | #2 |
Furbutts = LOVE Donating Member Moderator | Well, darn. Sure would be nice if the DOI was longer. I'll be interested to see what happens with Group 2. Perhaps that will prove more hopeful. Thanks, as always, for keeping us so informed!
__________________ ~ A friend told me I was delusional. I nearly fell off my unicorn. ~ °¨¨¨°ºOº°¨¨¨° Ann | Pfeiffer | Marcel Verdel Purcell | Wylie | Artie °¨¨¨°ºOº°¨¨¨° |
07-14-2013, 09:51 AM | #3 |
I♥PeekTinkySaph&Finny Donating Member Join Date: May 2009 Location: Baltimore, Maryland
Posts: 18,865
| Sounds promising! Thanks for posting!
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07-14-2013, 10:11 AM | #4 |
YT 2000 Club Donating Member | Thank you for posting this.
__________________ Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018 |
07-14-2013, 03:49 PM | #5 | |
And Rylee Finnegan Donating Member Join Date: Apr 2007 Location: Metro Detroit, MI
Posts: 17,928
| Quote:
With even memory cell protection looking questionable i wouldn't be comortable moving to every 5 years. Disappointing but thankful Dr. Schultz cares enough to do the study.
__________________ Crystal, Ellie May (RIP), Rylee Finnegan, and Gracie Boo🐶 | |
07-14-2013, 05:43 PM | #6 |
Action Jackson ♥ Donating Member Join Date: Dec 2008 Location: Maryland
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| Thanks for posting this great information!
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07-14-2013, 05:47 PM | #7 |
Donating YT 500 Club Member Join Date: Sep 2009 Location: Long Island, New York
Posts: 5,891
| I was hoping for longer also. I'm curious if the size of dog would be a factor. Yorkies get such a higher percentage of vaccine compared to other breeds based upon their small size, but I have no idea if this would affect how much immunity they would have.
__________________ Lisa and Katie Ashley 6/10, Gracie 2/04, Kiwi 10/03, and Jolie 7/93 . |
07-15-2013, 02:51 AM | #8 |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
| We are not done with the studies. The immunologic memory response findings were very high in the dogs tested with no or low RFFIT results. Those memory responses are a strong indication of protection, and based on that data, Dr. Dodds, Dr. Schultz and I expect the challenge to verify the results.
__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND |
07-15-2013, 02:54 AM | #9 |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
| There was nothing questionable about the immunologic memory response results, if they had been questionable, we would not be proceeding with the challenge of the first group of dogs.
__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND |
07-15-2013, 02:55 AM | #10 |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
| I believe this is very promising as well!
__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND |
07-15-2013, 02:56 AM | #11 |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
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__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND |
07-15-2013, 02:56 AM | #12 |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
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__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND |
07-15-2013, 03:00 AM | #13 | ||
And Rylee Finnegan Donating Member Join Date: Apr 2007 Location: Metro Detroit, MI
Posts: 17,928
| Quote:
Quote:
It will be interesting to see what the challenge study shows.
__________________ Crystal, Ellie May (RIP), Rylee Finnegan, and Gracie Boo🐶 | ||
07-15-2013, 05:36 AM | #14 | |
YT Addict Join Date: Jan 2008 Location: THE RABIES CHALLENGE FUND
Posts: 434
| Quote:
Of the 49 human cases of rabies reported by the Centers for Disease Control from 1995 through 2011, not one case was contracted from a dog or cat in the United States. 35 bats, 1 fox, 1 racoon, 1 mongoose CDC - Rabies Surveillance in the U.S.: Human Rabies - Rabies, so you can rest assured the data indicates the standard is working to protect humans even though there is estimated to be a large percentages of dog owners who never vaccinate their animals against rabies.
__________________ Kris L. Christine, Founder & Co-Trustee THE RABIES CHALLENGE FUND Last edited by Kris Christine; 07-15-2013 at 05:37 AM. | |
07-15-2013, 06:18 AM | #15 | ||
Furbutts = LOVE Donating Member Moderator | Quote:
Quote:
Plus, the titer results (in and of themselves) don't mean a whole lot. It's really the challenge that that will have meaning. In practice, titers are only accurate in as far as they may help confirm whether or not a dog has had a vaccine....titers do not confirm/prove immunity to the disease.
__________________ ~ A friend told me I was delusional. I nearly fell off my unicorn. ~ °¨¨¨°ºOº°¨¨¨° Ann | Pfeiffer | Marcel Verdel Purcell | Wylie | Artie °¨¨¨°ºOº°¨¨¨° | ||
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