See how she reacts to you putting your finger on her teeth as if you were putting the gel on there. If she's okay with that, then she should be just fine with the gel. I smelled it, and it doesn't smell too bad. My husband and I used it on Miko last night, and it wasn't too much of a struggle. But you can't let him eat or drink 30 min before or after you use it. Good luck, let us know how it goes