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-   -   Protein Lessing Nephraphy (https://www.yorkietalk.com/forums/yorkie-health-diet/292211-protein-lessing-nephraphy.html)

twister 01-09-2018 07:22 PM

Protein Lessing Nephraphy
 
I have a Yorkie who I was going to get spayed.She is 9 yrs old.Got blood work done and urine tested.Urine test came back she had protein in her urine.Vet said she has Protein Lessing Nephraphy.What could cause this and what is the outcome?All this came as a shock to me.The vet also said she has 2 little bumps on her mammary glands.So spay is on hold.Has anyone ever had this with there Yorkie?

pstinard 01-10-2018 05:06 AM

Quote:

Originally Posted by twister (Post 4748241)
I have a Yorkie who I was going to get spayed.She is 9 yrs old.Got blood work done and urine tested.Urine test came back she had protein in her urine.Vet said she has Protein Lessing Nephraphy.What could cause this and what is the outcome?All this came as a shock to me.The vet also said she has 2 little bumps on her mammary glands.So spay is on hold.Has anyone ever had this with there Yorkie?

Here is a good article about protein losing nephropathy: https://wagwalking.com/condition/pro...ng-nephropathy

Since it's a serious condition, you should definitely get a second opinion just to be sure of the diagnosis, or get a referral to a board-certified veterinary specialist in kidney diseases.

ladyjane 01-10-2018 08:04 AM

Yes, I have had 3 pups with this. One is currently living. You cannot diagnose a pup with PLN based on one urine test. Did the blood work show a lowered albumin? I am assuming it may have...or the vet would not have diagnosed this as protein can be in the urine for other reasons. Did they do a UPC? (urine protein creatinine ratio)

I would definitely hold off on surgery until all of this is clear.

If you can, a consult with an internal med specialist might be helpful, but isn't totally necessary. Your vet should know how to treat this.

With the first pup who was diagnosed with PLN I was told she had probably at most one year to live. She went on to live for 4 1/2 years. Here is a link to her story:

http://www.yorkietalk.com/forums/sic...phropathy.html

swgayorkie 01-11-2018 09:37 AM

Years ago I had an older female with PLE, Protien Loosing Enteropathy. Does anyone know if PLN is the same?

pstinard 01-11-2018 09:56 AM

Quote:

Originally Posted by swgayorkie (Post 4748349)
Years ago I had an older female with PLE, Protien Loosing Enteropathy. Does anyone know if PLN is the same?

No, they are different. PLE is loss of protein through the digestive tract (intestines). PLN is loss of protein through the kidneys (urine).

Wylie's Mom 01-12-2018 03:48 AM

This is probably my very favorite article on PLN, but it's very techy: VetFolio.

PLN is always caused by something *else* -- you need to find the underlying CAUSE! That is the vet's next step, unless they already know the underlying cause...?

ladyjane 01-12-2018 05:35 AM

Quote:

Originally Posted by Wylie's Mom (Post 4748426)
This is probably my very favorite article on PLN, but it's very techy: VetFolio.

PLN is always caused by something *else* -- you need to find the underlying CAUSE! That is the vet's next step, unless they already know the underlying cause...?

I believe most of the time it is genetic, but I could be wrong. That said, we did do an ultrasound on Olivia and also on Rookie. Rookie has both PLN and PLE and the specialist told me that having both is actually a common occurrence in yorkies. :( We can thank all of the indiscriminate breeding for that I am quite sure...and the never ending quest for the tiniest yorkie one can find. GRRRR

With the OP's dog, I spoke with her the other day and they are doing further testing to definitively diagnose this. If PLN is found early, it can be treated successfully is what I have found. Most of what I read in the beginning and what the specialist told me was life expectancy was about one year. Scared the heck out of me. In both Olivia and Rookie and in 107Barney's pup, Daisy, it was found during routine blood and urine testing....before symptoms were showing up. All three lived way beyond one year after diagnosis!! Rookie is still here with me. :) This is why I harp about yearly vet exams and lab testing.

Wylie's Mom 01-19-2018 10:14 AM

Linda - sometimes it can be genetic, but I think that's more breed specific. In most cases, PLN is caused by an underlying disease. In my foster Tucker's case, his PLN was either caused by his Erlichia or his pancreatitis - we can't be sure which :(.

The key to best prognosis is early diagnosis of PLN and identifying underlying cause and treating it in time.

And from that article - some other causes:

Diseases associated with glomerulonephritis in the dog include infectious diseases (heartworm disease, Ehrlichiosis, Lyme disease, Rocky Mountain Spotted Fever [RMSF], pyometra, chronic bacterial infections, bacterial endocarditis, septicemia, Brucellosis, Leishmaniasis, Trypanosoma, and infectious canine hepatitis), neoplasia, inflammatory diseases (pancreatitis, systemic lupus erythematosus [SLE], polyarthritis, chronic skin disease, and prostatitis), and other conditions (Cushing's disease, diabetes mellitus). In cats, GN can be associated with feline leukemia virus, feline infectious peritonitis, mycoplasmal polyarthritis, neoplasia, pancreatitis, SLE, other immune diseases, and diabetes mellitus. In many cases, an underlying cause cannot be discovered, and these are classified as idiopathic. Amyloidosis can be a familial disorder in Shar Pei dogs and Abbysinian cats, and it can also occur in conjunction with chronic antigenic stimulation (i.e. chronic pyoderma, neoplasia). Breeds with a high incidence of familial glomerulopathy include Soft-coated Wheaton Terriers and English cocker spaniels. Familial PLN has been reported in many other breeds.

ladyjane 01-19-2018 11:40 AM

Quote:

Originally Posted by Wylie's Mom (Post 4749127)
Linda - sometimes it can be genetic, but I think that's more breed specific. In most cases, PLN is caused by an underlying disease. In my foster Tucker's case, his PLN was either caused by his Erlichia or his pancreatitis - we can't be sure which :(.

The key to best prognosis is early diagnosis of PLN and identifying underlying cause and treating it in time.

And from that article - some other causes:

Diseases associated with glomerulonephritis in the dog include infectious diseases (heartworm disease, Ehrlichiosis, Lyme disease, Rocky Mountain Spotted Fever [RMSF], pyometra, chronic bacterial infections, bacterial endocarditis, septicemia, Brucellosis, Leishmaniasis, Trypanosoma, and infectious canine hepatitis), neoplasia, inflammatory diseases (pancreatitis, systemic lupus erythematosus [SLE], polyarthritis, chronic skin disease, and prostatitis), and other conditions (Cushing's disease, diabetes mellitus). In cats, GN can be associated with feline leukemia virus, feline infectious peritonitis, mycoplasmal polyarthritis, neoplasia, pancreatitis, SLE, other immune diseases, and diabetes mellitus. In many cases, an underlying cause cannot be discovered, and these are classified as idiopathic. Amyloidosis can be a familial disorder in Shar Pei dogs and Abbysinian cats, and it can also occur in conjunction with chronic antigenic stimulation (i.e. chronic pyoderma, neoplasia). Breeds with a high incidence of familial glomerulopathy include Soft-coated Wheaton Terriers and English cocker spaniels. Familial PLN has been reported in many other breeds.

Sadly, it is actually showing up more in yorkies. I know they are not on the "commonly found" list, but the specialist told me they see a lot.

I am not disputing the other issues/causes.

ladyjane 01-19-2018 11:45 AM

Oh, but yeah, let me add that I would not expect my vet to just assume it was genetic. Both of mine had full workups.

I just have a strong feeling that it is becoming more of a genetic issue in yorkies due to breeding...of course that is not based on anything but MY thoughts and the fact the vets see a lot in yorkies.

pstinard 01-22-2018 07:07 AM

Quote:

Originally Posted by ladyjane (Post 4749147)
Oh, but yeah, let me add that I would not expect my vet to just assume it was genetic. Both of mine had full workups.

I just have a strong feeling that it is becoming more of a genetic issue in yorkies due to breeding...of course that is not based on anything but MY thoughts and the fact the vets see a lot in yorkies.

It is not out of the realm of possibility that PLN in Yorkshire Terriers could have a genetic component. The University of Pennsylvania has developed a PLN DNA test for Soft Coated Wheaten Terriers and Airedale Terriers. See: SCWTCA - Genetic Testing for PLN-Associated Variant Genes

This test is currently available only for those two breeds, but I'll ask the primary researcher on the project if they have studied other terriers such as Yorkies and let you know what I find out...

pstinard 01-22-2018 02:24 PM

Quote:

Originally Posted by pstinard (Post 4749320)
It is not out of the realm of possibility that PLN in Yorkshire Terriers could have a genetic component. The University of Pennsylvania has developed a PLN DNA test for Soft Coated Wheaten Terriers and Airedale Terriers. See: SCWTCA - Genetic Testing for PLN-Associated Variant Genes

This test is currently available only for those two breeds, but I'll ask the primary researcher on the project if they have studied other terriers such as Yorkies and let you know what I find out...

I heard back from Dr. Meryl Littman of the University of Pennsylvania. No association between the mutant genes detected in Wheaten Terriers and Yorkies with PLN so far, so the DNA test does not appear to be applicable to Yorkies. I'm still in conversation with her, so I'll give another update later.

ladyjane 01-22-2018 04:13 PM

Quote:

Originally Posted by pstinard (Post 4749320)
It is not out of the realm of possibility that PLN in Yorkshire Terriers could have a genetic component. The University of Pennsylvania has developed a PLN DNA test for Soft Coated Wheaten Terriers and Airedale Terriers. See: SCWTCA - Genetic Testing for PLN-Associated Variant Genes

This test is currently available only for those two breeds, but I'll ask the primary researcher on the project if they have studied other terriers such as Yorkies and let you know what I find out...

I definitely will be interested in what you hear.

pstinard 01-24-2018 06:00 AM

Quote:

Originally Posted by pstinard (Post 4749362)
I heard back from Dr. Meryl Littman of the University of Pennsylvania. No association between the mutant genes detected in Wheaten Terriers and Yorkies with PLN so far, so the DNA test does not appear to be applicable to Yorkies. I'm still in conversation with her, so I'll give another update later.

Regrettably, Dr. Meryl Littman has retired and finished up her research on genetic tests for PLN in dogs. She spent many years on research with Soft Coated Wheaten Terriers, tracking medical records and genetic markers, but is not planning on continuing her research with other breeds. There *may* be a genetic component to PLN in Yorkshire Terriers, but it's probably not identical to the Wheatens, so the test is not a one-size-fits-all kind of test :(. The University of Pennsylvania will perform the test on other breeds such as Yorkshire Terriers, but it's not diagnostic for Yorkies, and it costs $125 (if I recall correctly), so I can't recommend it. Its primary use is to test Soft Coated Wheaten Terrier breeding stock to make sure that carriers of the mutant genes are not used in breeding programs.

ladyjane 01-24-2018 06:28 AM

Quote:

Originally Posted by pstinard (Post 4749514)
Regrettably, Dr. Meryl Littman has retired and finished up her research on genetic tests for PLN in dogs. She spent many years on research with Soft Coated Wheaten Terriers, tracking medical records and genetic markers, but is not planning on continuing her research with other breeds. There *may* be a genetic component to PLN in Yorkshire Terriers, but it's probably not identical to the Wheatens, so the test is not a one-size-fits-all kind of test :(. The University of Pennsylvania will perform the test on other breeds such as Yorkshire Terriers, but it's not diagnostic for Yorkies, and it costs $125 (if I recall correctly), so I can't recommend it. Its primary use is to test Soft Coated Wheaten Terrier breeding stock to make sure that carriers of the mutant genes are not used in breeding programs.

Thanks Phil. Sadly, things like this are not done until things are out of control. The link you posted referred to hundreds of Wheatens ... so, I am assuming it was a huge problem with them.


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