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10-29-2006, 11:02 AM | #1 |
Its all about the yorkies Donating Member Join Date: Sep 2006 Location: South Jersey
Posts: 1,451
| How breeding and cancer relate How breeding and cancer relate By WILLIAM H. SOKOLIC Courier-Post Staff The impact of breeding on the development of cancer is a difficult one to assess, experts say. Inappropriate breeding may lead to genetic abnormalities that result in an increased likelihood of developing cancer, said Dr. Ruthanne Chun, assistant professor of clinical oncology at Kansas State University. While breeding practices aim to preserve preferred traits, they may also predispose many dog breeds to genetic disorders, including cancer, says the National Institutes of Health. Inbreeding may select the bad as well as the good, said Dr. Patricia Fisher of the Garden State Animal Hospital in Cherry Hill. "Yet, it's difficult for breeders to know which dogs to breed and which not to breed," said Dr. Karin Sorenmo, an oncologist at the University of Pennsylvania School of Veterinary Medicine. "Most cancers we see are in animals middle age and older, with multiple genes involved. It's not so simple to say, "I found a gene and won't breed this dog,' " she said. That may be doable in the future now that canine gene sequences are mapped out, she said. "The vast majority of others are multifactorial. You may get a bad gene, but that would not cause cancer, but food, environment, etc., all come together to cause changes in the genetic code," said Dr. Philip J. Bergman, an oncologist and head of the Donaldson-Atwood Cancer Clinic & Flaherty Comparative Oncology Laboratory in New York. Still, some breeders take genetic problems seriously. "They've started to elucidate the genetic mechanism and try to breed them out of lines," Bergman said. Studies indicate that certain breeds are more prone to develop cancer, Bergman said. "I learned goldens have a tendency toward a higher rate of cancer," said Melissa Harned, whose dog, Shaymus, has lymphoma. Retrievers, as well as German shepherds, Portuguese water dogs and Skye terriers are more apt to come down with hemangiosarcoma, cancer of the blood vessels. Scotties, black Labradors, black poodles and pugs tend to have melanoma at a higher rate than other species. English setters, Chihuahua, miniature poodles and Afghan hounds have a predilection for invasive mammary gland cancers. Mast cell cancers are prevalent in boxers, American Staffordshire terriers, Chinese Shar-Pei and Boston terriers while Bernese mountain dogs are prone to malignant histiocytosis, a cancer of the white blood cells. Body type is also implicated. Large and giant dogs have a higher incidence of bone cancer (osteosarcoma) associated with stress on weight-bearing limbs, and dogs with dark skin are more susceptible to melanomas. Reach William H. Sokolic at (609) 823-9159 or wsokolic@courierpostonline.com Published: October 29. 2006 3:10AM
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