YorkieTalk.com Forums - Yorkshire Terrier Community


Welcome to the YorkieTalk.com Forums Community - the community for Yorkshire Terriers.

You are currently viewing our boards as a guest which gives you limited access to view most discussions and access our other features. By joining our free community you will have access to post topics, communicate privately with other members (PM), respond to polls, upload content and access many other special features. You will be able to chat with over 35,000 YorkieTalk members, read over 2,000,000 posted discussions, and view more than 15,000 Yorkie photos in the YorkieTalk Photo Gallery after you register. We would love to have you as a member!

Registration is fast, simple and absolutely free so please, join our community today!

If you have any problems with the registration process or your account login, please click here to contact us.

Go Back   YorkieTalk.com Forums - Yorkshire Terrier Community > Breeding / Showing / Traveling > Breeder Talk
Register Blogs FAQ Calendar

Reply
 
LinkBack Thread Tools
Old 11-28-2010, 03:50 PM   #1
YT 2000 Club
Donating Member
 
gemy's Avatar
 
Join Date: Oct 2009
Location: Huntsville,Ont,Canaada
Posts: 12,335
Blog Entries: 2
Default Canine Hyperuricosuria

Hperuricosuria means elevated levels of uric acid in the urine. This trait predisposes dogs to form stones in their bladders of sometimes kidneys. These stones often must be removed surically and can be difficult to treat. Hyperusicosuria is inherited as as simple autosomal recesssive trait. A mutation in exon 5 of the gene Sofute carrier family 2 member 9 has been found to be associated with hyperuricosuria in dogs. A DNA test for this specific mutation can determin if dogs are normal or if they carry one or two copies of the mutation. |Dogs that carry two copies of the mutation will be affected and susceptible to develop bladder/kidney stones.

UC Davis offers testing kits. It is I believe around $60 per test.

UC Davis recommends testing any dog that has formed kidney or bladder stones comprised of urate or uric acid

I was at a breeding seminar for BRT's where we had a lecture about this condition. The lecturer shared that for Dalmations in Canada and the USA, this condition is rife, in fact so much so, that there are very few if any dogs not affected, so they are now looking to Europe in hopes of finding clear dogs.

This is a painfull condition and oftentimes affects males more than females.
__________________
Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018
gemy is offline   Reply With Quote
Welcome Guest!
Not Registered?

Join today and remove this ad!

Old 11-28-2010, 06:45 PM   #2
Donating Member
 
Woogie Man's Avatar
 
Join Date: Feb 2008
Location: Mississippi
Posts: 2,564
Default

I have heard of urinary tract problems in Dalmations. I posted earlier about one researcher that crossed a Pointer with a Dalmation in order to produce clear dogs, so this must be an endemic problem with the breed to resort to such a drastic measure. Here's the bit about it.

~~~~~~~~~~~~~~~~~~~

"About fifteen years ago a researcher crossed a pointer with a Dalmatian and then back-crossed to Dals in subsequent generations. He successfully met his goal of eliminating inherited urinary problems that are present in almost every Dalmatian. The board of the breed club petitioned AKC to admit some of the products of this breeding program � dogs which had only one Pointer in a five-generation pedigree full of Dalmatians. Two of the dogs were admitted, but the breed club�s membership raised a hue and cry, voting to rescind the request. AKC refused any further registration of the �cross-bred� dogs.

The membership of the breed club rejected these dogs because they were often mis-marked, allowing a cosmetic problem that might have been corrected in subsequent generations to take precedence over the elimination of a significant breed health problem."


Form this link........Australian Shepherd Health & Genetics Institute, Inc.

~~~~~~~~~~~~~~~~~~~~~~~

Gail, did the lecturer indicate this was a problem with other breeds and was there a recommendation for asymptomatic dogs to be tested with this specific test as part of a pre-breeding protocol?
__________________
ORANGUTANS ARE DYING FOR THE SAKE OF CHEAP PALM OIL....AND YOU USE IT!!!
http://www.yorkietalk.com/forums/ani...m-oil-you.html
Woogie Man is offline   Reply With Quote
Old 11-28-2010, 09:02 PM   #3
Donating Member
 
Woogie Man's Avatar
 
Join Date: Feb 2008
Location: Mississippi
Posts: 2,564
Default

I did a little looking around since my last post and it seems that Dalmations are uniquely affected by this. Here's a link with some info...

Uric Acid Stones in Dalmatians

Here's some more info from the DCA....

Dalmatian Club of America - 15 Years' Data of Almost 3000 Dalmatian Urinary Stones

Here's the link for the genetic test available....

Hyperuricosuria

Here's a short quote from the link.....

"The trait can occur in any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier. Dalmatians are considered to be homozygous for hyperuricosuria."
__________________
ORANGUTANS ARE DYING FOR THE SAKE OF CHEAP PALM OIL....AND YOU USE IT!!!
http://www.yorkietalk.com/forums/ani...m-oil-you.html
Woogie Man is offline   Reply With Quote
Old 11-29-2010, 12:47 AM   #4
YT 2000 Club
Donating Member
 
gemy's Avatar
 
Join Date: Oct 2009
Location: Huntsville,Ont,Canaada
Posts: 12,335
Blog Entries: 2
Default

Quote:
Originally Posted by Woogie Man View Post
I did a little looking around since my last post and it seems that Dalmations are uniquely affected by this. Here's a link with some info...

Uric Acid Stones in Dalmatians

Here's some more info from the DCA....

Dalmatian Club of America - 15 Years' Data of Almost 3000 Dalmatian Urinary Stones

Here's the link for the genetic test available....

Hyperuricosuria

Here's a short quote from the link.....

"The trait can occur in any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier. Dalmatians are considered to be homozygous for hyperuricosuria."
Yes Jim and exactly the breeds you found mentioned as well. The lecturer did not go so far as to say all breeds should be tested, but of course my breed is one that should be tested prior to breeding.

UC Davis general recommendation is to test for this gene marker if there is a history of bladder stones. Of course in breeding dogs, the problem can show up well after being bred. Just another reason for breeders to know well the health history of their lineage.

This test is open to all breds of dogs by UC Davis.
__________________
Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018
gemy is offline   Reply With Quote
Old 11-29-2010, 01:27 AM   #5
Donating YT 500 Club Member
 
lisaly's Avatar
 
Join Date: Sep 2009
Location: Long Island, New York
Posts: 5,891
Default

I''m sure it is very painful for them. Is there anything other than diet that can prevent them in dogs that are predisposed to this? Is lithotripsy to blast out the stones an option rather than surgery or is the cost too prohibitive? This sounds so scary and my heart breaks to hear of dogs having to go through so much pain.
__________________
Lisa and Katie

Ashley 6/10, Gracie 2/04, Kiwi 10/03, and Jolie 7/93 .
lisaly is offline   Reply With Quote
Old 11-29-2010, 01:59 AM   #6
YT 2000 Club
Donating Member
 
gemy's Avatar
 
Join Date: Oct 2009
Location: Huntsville,Ont,Canaada
Posts: 12,335
Blog Entries: 2
Default INHERITANCE PATTERNS for this Gene

Nomenclature N/N equals normal dog carries no copy of the gene

N/HU dog carries one copy of the gene - will not be affected by disease

HU/HU dog has two copies of the gene is susceptible to bladder stones.formed of urate or uric acid.

Say you have a male sire let's call him Max and you breed him once. Sometime later on you find out he has bladder stones formed of uric acid. You now know that he is a HU/HU.

If you bred him to a N/N female then these offspring will all have one copy of the gene present 100% N/HU. They are all carriers.

If the female in this case was a carrier of the gene herself N/HU then these offspring will have a 50% chance of being HU/HU and a 50% chance of being carriers N/HU.

As you can clearly see it won't take long for this to go through a breed if testing is not done.

Should you breed a carrier to a carrier N/HU to N/HU the stats for this come out as follows 25% N/N 50% N/HU 25% HU/HU

So what to do as a guardian of this breed? Be you a breeder or a lover of Yorkies


In my opinion if you have a pet that does form these stones, please get back to the breeder you bought from, and inform them of this condition. Also if you can, inform both sides of the equation, ie: the sire's owners as well as the bitch's.

As a breeder; a conservative approach would be to test your breeding stock to see just what you have in terms of this gene. If you have a carrier, then I would want to have the bitch/sire I wish to breed with checked out for their status. Remember if you breed a carrier to a carrier you will produce 25% puppies which will have hyperuricosia, and 50% carriers.Or another way of looking at this is 3/4 of the litter have either one or two copies of the gene present.

An affected dog quite simply shouldn't be bred.
__________________
Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018
gemy is offline   Reply With Quote
Old 11-29-2010, 12:23 PM   #7
YT 2000 Club
Donating Member
 
gemy's Avatar
 
Join Date: Oct 2009
Location: Huntsville,Ont,Canaada
Posts: 12,335
Blog Entries: 2
Default

Quote:
Originally Posted by lisaly View Post
I''m sure it is very painful for them. Is there anything other than diet that can prevent them in dogs that are predisposed to this? Is lithotripsy to blast out the stones an option rather than surgery or is the cost too prohibitive? This sounds so scary and my heart breaks to hear of dogs having to go through so much pain.
Lisa; I've linked this article from UCDavis It doesn`t speak about lithotripsy here. May be other research and protocols that I`ve not seen yet. But you know the saying prevention is worth a pound of cure. If my boy tests as HU HU he will start on proper diet and urine monitoring protocols.

Uric Acid Stones//Urate Urolithiasis - VeterinaryPartner.com - a VIN company!
__________________
Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018
gemy is offline   Reply With Quote
Old 11-29-2010, 09:32 PM   #8
Donating YT 500 Club Member
 
lisaly's Avatar
 
Join Date: Sep 2009
Location: Long Island, New York
Posts: 5,891
Default

I agree, Gail. Prevention is always the key. You won't need to go further medically if you can prevent it in the first place. I was curious about whether lithotripsy was possible for dogs. It won't work on most Yorkies because they say dogs need to be greater than 16 pounds. They are now doing something called laser lithotripsy, which is effective and far less invasive for the dog. It's only available a few places, but it is definitely something to look into as an alternative to surgery. My husband, John, had several bouts of kidney stones many years ago. At the time there was only one place on Long Island, New York to have lithotripsy done, so it took weeks to get an appointment. He needed treatment that would allow him to wait those few weeks until he could get them blasted. Other hospitals had something that put a person in water where they would try to blast them that way, but it wasn't as effective. Today, the places that do lithotripsy are more readily available, but it is very expensive, about $15,000 fifteen years ago. Now that there are more available, I wonder if the cost is less. We were insured, so at least we were lucky. I wonder if they would cover these treatments for dogs with health insurance.
Laser lithotripsy now available at VTH — College Of Veterinary Medicine at Michigan State University
http://www.vet.ohio-state.edu/assets...winter2008.pdf p. 3
__________________
Lisa and Katie

Ashley 6/10, Gracie 2/04, Kiwi 10/03, and Jolie 7/93 .
lisaly is offline   Reply With Quote
Old 11-30-2010, 01:51 AM   #9
YT 2000 Club
Donating Member
 
gemy's Avatar
 
Join Date: Oct 2009
Location: Huntsville,Ont,Canaada
Posts: 12,335
Blog Entries: 2
Default

Quote:
Originally Posted by lisaly View Post
I agree, Gail. Prevention is always the key. You won't need to go further medically if you can prevent it in the first place. I was curious about whether lithotripsy was possible for dogs. It won't work on most Yorkies because they say dogs need to be greater than 16 pounds. They are now doing something called laser lithotripsy, which is effective and far less invasive for the dog. It's only available a few places, but it is definitely something to look into as an alternative to surgery. My husband, John, had several bouts of kidney stones many years ago. At the time there was only one place on Long Island, New York to have lithotripsy done, so it took weeks to get an appointment. He needed treatment that would allow him to wait those few weeks until he could get them blasted. Other hospitals had something that put a person in water where they would try to blast them that way, but it wasn't as effective. Today, the places that do lithotripsy are more readily available, but it is very expensive, about $15,000 fifteen years ago. Now that there are more available, I wonder if the cost is less. We were insured, so at least we were lucky. I wonder if they would cover these treatments for dogs with health insurance.
Laser lithotripsy now available at VTH — College Of Veterinary Medicine at Michigan State University
http://www.vet.ohio-state.edu/assets...winter2008.pdf p. 3

Great Link Lisa. thanks
__________________
Razzle and Dara. Our clan. RIP Karma Dec 24th 2004-July 14 2013 RIP Zoey Jun9 th 2008-May 12 2012. RIP Magic,Mar 26 2006July 1st 2018
gemy is offline   Reply With Quote
Reply

Bookmarks




Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off




Google
 

SHOP NOW: Amazon :: eBay :: Buy.com :: Newegg :: PetStore :: Petco :: PetSmart


All times are GMT -8. The time now is 02:21 PM.


Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright ©2003 - 2018 YorkieTalk.com
Privacy Policy - Terms of Use

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736 737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 764 765 766 767 768 769 770 771 772 773 774 775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 790 791 792 793 794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 828 829 830 831 832 833 834 835 836 837 838 839 840 841 842 843 844 845 846 847 848 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 867 868 869 870 871 872 873 874 875 876 877 878 879 880 881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 896 897 898 899 900 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 1022 1023 1024 1025 1026 1027 1028 1029 1030 1031 1032 1033 1034 1035 1036 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 1071 1072 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1102 1103 1104 1105 1106 1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121 1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 1136 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167