The Topamax does have the side effect of weight loss, good for some...but I have never heard of it having such ill effects toward mood/depression. All medicines affect individuals differently. I have had nasty side effects from meds that were no where listed on their warning lists, so I can relate. The Elavil is a tricyclic antidepressant that has also been used off-label to treat chronic pain and migraines. I would definately give it a shot, it has been around a long time and is a safe drug if used appropriately. That alone may help with the migraines. What else have they tried? I know there is another drug on the market, similar to Imitrex I think, call Relpax that a lot of my coworkers have used successfully. I will ask aorund at work and see what else we can come up with (I am a nurse, so it will be a few days, but can get some MD advice for you.) Good luck.
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